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Starting with a small dose allows the body to adjust to the medication

The compound exists, for practical purposes, as a subject of academic interest in animal studies and as a product available from gray-market vendors and nowhere else in the supply chain

Lee, C., Zeng, J., Drew, B

Other Interactions with Suboxone (Use Caution) The medical literature generally advises caution rather than outright avoidance with these substances

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In practical terms, both compounds currently sit in a transitional regulatory status: no longer explicitly restricted, but not yet authorized for routine compounding either